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Memantine is primarily prescribed to older adults, although it is sometimes used off-label to treat rapid eye movements (nystagmus), a problem that can happen at any age. There is no data concerning the safety of memantine to a developing fetus, though animal studies suggest it may cause developmental problems. The use of memantine during pregnancy is a decision that a woman and her healthcare provider will need to make.
best place to buy memantine
Just as memantine has few side effects and only a few warnings, it also has few drug interactions that are a cause for concern. No drugs are strictly prohibited, but a few might require extra monitoring for side effects.
The most concerning are drugs that compete with memantine in being filtered by the kidneys. This includes the diabetes drug metformin. When combined with memantine, they can significantly increase memantine levels in the body or memantine can increase their levels. Whatever the effect, the risk of side effects goes up. Healthcare providers will more closely watch for side effects when giving memantine with any of these drugs.
A few drugs and supplements can cause problems when taken with memantine, so make sure the prescriber knows about all the prescription drugs, over-the-counter medicines, vitamins, and dietary supplements being given to the patient.
Context Memantine is a low- to moderate-affinity, uncompetitive N-methyl-D-aspartate receptor antagonist. Controlledtrials have demonstrated the safety and efficacy of memantine monotherapyfor patients with moderate to severe Alzheimer disease (AD) but no controlledtrials of memantine in patients receiving a cholinesterase inhibitor havebeen performed.
Design, Setting, and Participants A randomized, double-blind, placebo-controlled clinical trial of 404patients with moderate to severe AD and Mini-Mental State Examination scoresof 5 to 14, who received stable doses of donepezil, conducted at 37 US sitesbetween June 11, 2001, and June 3, 2002. A total of 322 patients (80%) completedthe trial.
Conclusions In patients with moderate to severe AD receiving stable doses of donepezil,memantine resulted in significantly better outcomes than placebo on measuresof cognition, activities of daily living, global outcome, and behavior andwas well tolerated. These results, together with previous studies, suggestthat memantine represents a new approach for the treatment of patients withmoderate to severe AD.
Memantine prescription medication is marketed under the brand name Namenda and is sometimes prescribed for the treatment of Alzheimer's type dementia. Memantine HCl belongs to a class of medications known as N-methyl-D-aspartate (NMDA) receptor antagonists. Memantine medication may also improve cognitive function. Memantine prescription tablets are sometimes started as memantine 5 mg once daily and titrated from there, depending on the needs and response of the patient. Generic memantine tablets are affordable, costing approximately 20 cents per memantine 10 mg tablet at many pharmacies. Additionally, memantine coupons can sometimes be found online and some insurance plans may help with costs associated with memantine prescription tablets.
Memantine medication requires a prescription in the United States before it can be purchased at a pharmacy. Memantine OTC is not available and one cannot simply buy memantine online from a pharmacy without first getting a memantine prescription from a licensed medical provider. People who might need a memantine prescription, however, can use Push Health to connect with a medical provider online who can prescribe memantine medication, including generic memantine 5 mg and memantine 10 mg tablets, when appropriate to do so.
Memantine medication can cause side effects when used but is generally tolerated well. Adverse effects that can occur while using memantine medication include headache, constipation, dizziness and confusion. Prior to using memantine HCl medication, concerns about memantine tablet use should be discussed with a pharmacist. Memantine tablets should typically not be used with alcohol or tobacco. People with a hypersensitivity to memantine medication or similar drugs should avoid using memantine prescription medication.
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.
This list is not complete. Other drugs may interact with memantine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
In the present study, we used behavioral techniques to test two related hypotheses regarding a potential role for NMDARs in the pathogenesis of DS: (1) if CaN activity levels in Ts65Dn brains are reduced sufficiently, Ts65Dn mice should also display increased sensitivity to MK-801; and (2) because the uncompetitive NMDAR antagonist memantine produces changes on NMDAR kinetics that at least qualitatively mimic the actions of CaN at the single channel level (Chen et al, 1992), this drug may partially restore the physiological function of NMDAR and potentially improve learning and memory in these animals.
We used a simple fear conditioning protocol to test the capacity for contextual memory of 4- to 6-month-old Ts65Dn mice compared to euploid control mice of the same age. During the context test, saline-injected control mice (n=10) displayed a larger percentage of freezing compared to saline-injected Ts65Dn mice (n=10) (Figure 2a). Therefore, we investigated whether the uncompetitive antagonist memantine might rescue this phenotype. We found that memantine-treated Ts65Dn mice (n=10) displayed freezing at a comparable percentage to both saline-injected and memantine-treated control animals (n=10). Two-way ANOVA revealed that both genotype (F(1,36)=21.009, *p
Memantine rescues performance deficits of 4- to 6-month-old Ts65Dn mice on a fear conditioning test. Bar graphs in (a and b) represent mean percentage freezing (SEM) during the context test. (a) In a context-shock protocol, saline-injected euploid control mice (n=10) displayed freezing for about 50% of the total time, whereas saline-injected Ts65Dn mice (n=10) displayed freezing behavior for only about 15% of the total time. In contrast, memantine-treated Ts65Dn mice (n=10) displayed freezing at a comparable percentage to both saline-injected and memantine-treated control animals (n=10). (b) Mice that were exposed to the shock-context protocol, irrespective of genotype, did not acquire conditioned fear, despite exposure to the shock and memantine treatment (n=10 for each group).
To investigate a potential age-dependence of the memory/learning enhancing effect of memantine on Ts65Dn mice, we repeated the same fear conditioning protocol used with 4- 6-month-old Ts65Dn mice on separate groups of Ts65Dn mice ranging between 10 and 14 months of age (Figure 4a). As with 4- to 6-month-old mice, we found that both genotype (F(1,36)=11.356, *p=0.0018) and drug treatment (F(1,36)=5.860, *p=0.0207) had significant effects on the percentage of freezing during the context test. We also detected a significant interaction between genotype and drug treatment (F(1,36)=4.166, *p=0.0486). Among the two groups that received saline injections, euploid control mice (n=10) displayed a significantly larger percentage of freezing during the context test than Ts65Dn mice (n=10; *p=0.0005). In contrast, among the mice that received memantine injections, there was no significant difference in freezing behavior between control (n=10) and Ts65Dn mice (n=10; p=0.3536). There were also no significant differences between the two groups of euploid control mice (p=0.7899) or between the Ts65Dn mice that received memantine injections and the euploid control mice that received only saline injections (p=0.5064). Furthermore, both the euploid controls (*p=0.0002) and the Ts65Dn mice (*p=0.0032) that received memantine injections displayed freezing behavior for a significantly larger percentage of time during the context test than saline-injected Ts65Dn mice.
Memantine also rescues performance deficits of 10- to 12-month-old Ts65Dn mice on a fear conditioning test. Bar graphs in (a and b) represent mean percentage freezing (SEM) during the context test. (a) In a context-shock protocol, saline-injected euploid control mice (n=10) displayed freezing for about 50% of the total time, saline-injected Ts65Dn mice (n=10) displayed freezing behavior for only about 20% of the total time. Memantine-treated Ts65Dn mice (n=10) displayed a comparable percentage of freezing behavior as saline-injected and memantine-treated control animals (n=10). (b) Mice that were exposed to the shock-context protocol, irrespective of genotype, did not acquire conditioned fear (n=8 for each group).
In light of our findings, some clear directions for future studies include: (1) search for the most effective dose and injection regimen for memantine in Ts65Dn mice; (2) investigation of molecular correlates, such as in NMDAR phosphorylation levels and ion channel gating kinetics; (3) study of the chronic exposure of Ts65Dn mice to this compound and (4) investigation of a potential neuroprotective role of memantine in Ts65Dn mice.
Recently, Fernandez et al (2007) demonstrated that memory and learning deficits in Ts65Dn mice can be reversed by the chronic administration of clinically subepileptogenic doses of GABAA receptor antagonists. To our knowledge, however, the present work is the first instance in which the acute injection of a pharmacological agent has improved the behavioral performance of Ts65Dn mice in a test of learning and memory. These results are quite exciting from a potential therapeutic perspective, given the current status of memantine as an FDA-approved drug and given that the dose of memantine used here is likely to be therapeutically relevant. 041b061a72